Course Unit (CU) : Analysing of individual PK data Linear PK concept
– Model-dependent analysis : main models, mathematical concepts
– NCA (non-compartmental analysis)
– « Two-stage approach » et clinical trials
– Patients with impaired renal or hepatic function, elderly, pediatrics, drug-drug interactions
– Analytical issues : assay validation
– PK and drug regulatory (human and veterinary drugs) : Bioequivalence
– Applied exercises : Personal tasks

CU: Population PK analysis
· Concepts and methodologies in POP-PK
· Use of NONMEM, MONOLIX, R (tutorial classes)
· Applied exercises: 1 ECTS (Personal tasks)
· POP-PK applied to Therapeutic Drug Monitoring, medical imagery
· Machine learning applied to PK: 0.5 ECTS

CU: Pharmacokinetic/Pharmacodynamics Modelling (PK-PD)
· Building of PK/PD models
· Pharmacodynamics and different kinds of models
· PK/PD analysis of data (applied exercises)
· PK/PD workshop

CU : Pre- and post-processing
· Pre-processing
· Data management
· Building of dataset
· Post-processing / data science
· Applied exercises : models evaluations, goodness-of-fit (R)
· Data simulations

CU : Physiologically based PK modelling (PB/PK)
· Principles of PB/PK
· Applications of PB/PK : interspecies extrapolations, in vitro/in vivo extrapolations
· Building a PB/PK model from physiological parameters and drug characteristics
· Simulations and interpretations

CU : Applications of PK/PD
· Regulatory for human and veterinary drugs : bioequivalence
· Veterinary drugs
· PK/PD of antibiotics
· PK/PD in oncology

CU : Project development